![]() ![]() Kickler N, Lacombe E, Chassain C, Durif F, Krainik A, Farion R, et al. An in vivo ultrahigh field 14.1 T 1H-MRS study on 6-OHDA and alpha-synuclein-based rat models of Parkinson’s disease: GABA as an early disease marker. 2017 30(2):e3686.Ĭoune PG, Craveiro M, Gaugler MN, Mlynarik V, Schneider BL, Aebischer P, et al. Neurometabolic profiles of the substantia nigra and striatum of MPTP-intoxicated common marmosets: an in vivo proton MRS study at 9.4 T. Heo H, Ahn J-B, Lee HH, Kwon E, Yun J-W, Kim H, et al. Metabolic changes detected in vivo by 1H MRS in the MPTP-intoxicated mouse. Changes in the metabolic profiles of the serum and putamen in Parkinson’s disease patients – in vitro and in vivo NMR spectroscopy studies. Toczylowska B, Zieminska E, Michałowska M, Chalimoniuk M, Fiszer U. ![]() Dopamine reduction in the substantia nigra of Parkinson’s disease patients confirmed by in vivo magnetic resonance spectroscopic imaging. Smeyne RJ, Gröger A, Kolb R, Schäfer R, Klose U. ![]() Alterations in the distribution of glutathione in the substantia nigra in Parkinson’s disease. Pearce RKB, Owen A, Daniel S, Jenner P, Marsden CD. Quantitative proton magnetic resonance spectroscopy and spectroscopic imaging of the brain: a didactic review. The neurochemical profile quantified by in vivo 1H NMR spectroscopy. Glutathione and glutamate in schizophrenia: a 7T MRS study. Kumar J, Liddle EB, Fernandes CC, Palaniyappan L, Hall EL, Robson SE, et al. Evaluation of markers of oxidative stress, antioxidant function and astrocytic proliferation in the striatum and frontal cortex of Parkinson’s disease brains. Mythri RB, Venkateshappa C, Harish G, Mahadevan A, Muthane UB, Yasha TC, et al. Increase in external glutamate and NMDA receptor activation contribute to H 2O 2-induced neuronal apoptosis. Mailly F, Marin P, Israel M, Glowinski J, Premont J. Iron-melanin interaction and lipid peroxidation: implications for Parkinson’s disease. Disruption of mitochondrial complex I induces progressive parkinsonism. González-Rodríguez P, Zampese E, Stout KA, Guzman JN, Ilijic E, Yang B, et al. Oxidative stress and the pathogenesis of Parkinson’s disease. Preclinical 1H-MRS neurochemical profiling in neurological and psychiatric disorders. Lee MR, Denic A, Hinton DJ, Mishra PK, Choi D-S, Pirko I, et al. Targeting the progression of Parkinson’s disease. George JL, Mok S, Moses D, Wilkins S, Bush AI, Cherny RA, et al. Patterns of loss of dopamine-containing neurons in Parkinson’s disease. Graphical abstractĭamier P, Hirsch EC, Agid Y, Graybiel AM. The results from this study also highlighted (1) the need to be cautious when interpreting the in vivo 1H-MRS results obtained from aged transgenic animals, in which the concentration of internal reference, being whether water or total creatine, could no longer be assumed to be the same as that in the age-matched WT animals, and (2) the necessity and importance of complementary analyses with more than one method under such circumstances. Convergingly, the results obtained with the two methods demonstrated that, compared with the wild-type (WT) mice, the DJ-1 knockout mice had significantly increased glutathione (GSH) level and GSH/glutamate (Glu) ratio in the mPFC, which likely presented an astrocytic compensatory mechanism in response to elevated regional oxidative stress induced by the loss of DJ-1 function. In this study, the two methods were used complementarily, in parallel, to investigate neurochemical perturbations in the medial prefrontal cortex (mPFC) of 9-month-old DJ-1 knockout mice, a well-established transgenic model for Parkinson’s diseases. ![]() In vivo proton magnetic resonance spectroscopy ( 1H-MRS) and matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) are two semi-quantitative analytical methods commonly used in neurochemical research. ![]()
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